Cardiac glycosides
Compilation and arrangement of Engineer Javidi
Description:
-Glycosidic compounds with lactone ring in beta position, carbon number 17 are available.
– The sugar sequence using the hydroxyl group of the steroid aglycone at carbon 3 is in the form of a glycoside. (Aglycone has a 4-ring steroid with 3 and 4 hydroxyl groups).
These compounds are very toxic and are only used in the pharmaceutical industry for heart ailments.
Introduction of some cardiac glycosides:……………………
– Coanuloside: in the snow flower plant (Convallaria) from the Liliaceae family.
– Sillarin A – Procilaribis: in the sea onion plant from the Liliaceae family
-Digoxin: in Foxglove plant from the monkey flower family.
-Odoroside – Oleandrin: in the Oleander plant from the Apocynaceae family
– Stropantin: in a plant from the Apocynaceae family
Hellebrine: in Virids hellborus from Liliaceae family
Function of digoxin in the body:………………..
-Increasing the speed and power of systolic contraction of the heart and reducing the duration of systole (ventricles are completely empty, in this state the heart rests between two contractions) -Increasing cardiac output -Increasing renal excretion -Positive entropic effect (increasing heart muscle contraction) – Increases cardiac arrhythmia (increased atrial and ventricular muscle excitation) – Increases heart muscle sensitivity to vagus nerve impulses.
Good luck – Javidi
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